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Enzyme kinetic values attained from multisite equation for midazolam (MDZ) glucuronidation by human liver microsomes (HLM) and rUGT1A4
| MDZ | ||
|---|---|---|
| Parameters | HLM | rUGT1A4 |
| Vmax (pmol min−1 mg−1) | 445 ± 1 | 427 ± 0.5 |
| Ks (µM) | 46 ± 5 | 64 ± 6.4 |
| Ki (µM) | 58 ± 6 | 79 ± 8 |
| α | 18.3 ± 0.0007 | 14.9 ± 0.0008 |
| n | 2.3 ± 0.05 | 2.6 ± 0.07 |
| R2 | 0.962 | 0.986 |
