Table 1.

Estimated geometric group means of key pharmacokinetic parameters with 95% confidence intervals

Analyte	Group	AUC∞	Cmax	T1/2	CLR
		[h µg−1 ml−1]	[µg ml−1]	(h)	[ml h−1]
Tomopenem	Young men	208 (184, 236)	88.3 (78.4, 99.3)	2.03 (1.87–2.22)	3.52 (2.83, 4.38)
	Elderly men	254 (224, 287)	88.5 (78.6, 99.6)	2.41 (2.22–2.64)	3.67 (2.95, 4.57)
	Elderly women	301 (267, 340)	110 (97.9, 124.1)	2.27 (2.13–2.44)	2.83 (2.28, 3.52)
RO4957463	Young men	21.0 (18.0, 24.6)	5.28 (4.35, 6.40)	2.53 (2.19–3.04)	9.84 (8.09, 11.973)
	Elderly men	29.3 (25.1, 34.3)	4.83 (3.98, 5.86)	4.22 (3.60–5.10)	8.63 (7.10, 10.50)
	Elderly women	35.8 (30.7, 41.9)	6.26 (5.16, 7.59)	3.89 (3.39–4.60)	5.87 (4.83, 7,14)