Table 1.

Correlation of integrin β3 mRNA, VEGF protein and MDV with clinicopathological features

Clinicopathological parameters	n	Integrin β3 mRNA	VEGF							MVD
		-	+ - +++	χ2	P	-	+ - +++	χ2	P	n/mm2	t	P
Growth pattern	118			8.42	< 0.01			10.44	< 0.01		3.92	< 0.01
Expansive	51	32	19			32	19			49.45 ± 21.72
Infiltrative	67	24	43			22	45			64.06 ± 18.76
Histological grade (G)				6.47	< 0.05			3.49	0.062		1.25	> 0.05
G1 + G2	70	40	30			37	33			55.72 ± 21.56
G3 + G4	48	16	32			17	31			60.70 ± 20.73
Invasive depth				26.60	< 0.01			34.19	< 0.01		6.41	< 0.01
T1-T2	47	36	11			37	10			44.42 ± 19.96
T3-T4	71	20	51			17	54			66.56 ± 17.23
Vessel invasion				32.13	< 0.01			39.96	< 0.01		7.96	< 0.01
No	29	27	2			28	1			35.68 ± 14.04
Yes	89	29	60			26	63			64.93 ± 18.07
Lymph node metastasis				31.85	< 0.01			34.71	< 0.01		8.45	< 0.01
No	34	30	4			30	4			37.60 ± 15.73
Yes	84	26	58			24	60			66.24 ± 17.24
Distant metastasis									< 0.01
No	63	48	15			50	13			42.81 ± 17.23
Liver metastasis	20	4	16	20.48a	< 0.01a	3	17	27.25a	< 0.01a	73.40 ± 8.07	7.65a	< 0.01a
Peritoneal dissemination	35	4	31	34.72b	< 0.01b	1	34	52.77b	< 0.01b	75.79 ± 9.48	10.46b	< 0.01b

^aCompared between patients with liver metastasis and those without distant metastasis.

^bCompared between patients with peritoneal dissemination and those without distant metastasis.