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. 2009 May 18;4(5):e5577. doi: 10.1371/journal.pone.0005577

Figure 7. SALL4 represses the transcriptions of PTEN and SALL1 in vivo.

Figure 7

Cystic kidneys were observed in 50% of the SALL4B transgenic mice. (A) MRI imaging on mouse kidneys. Compared to the control normal kidney, the cystic kidney had a 1.35 mm cyst that is indicated by an arrow. The gross picture of a cystic kidney was shown in (B) with the arrow indicating the cystic area. (C) Histological morphologies on normal kidney (C–I, magnification: ×40) and cystic kidneys (C-ii and C-iii indicated by the arrow, ×40) were presented after stained with Hematoxylin and Eosin (H&E stain). (D) Normal bone marrow from control mice (H&E stain with magnification: ×100). (E) Leukemic bone marrow from transgenic mice (H&E stain with magnification: ×100). (F) The transcriptions of PTEN or SALL1 were decreased 20% and 45% respectively in SALL4B transgenic mice BM or kidney samples. Data represent as mean±SD, n = 4, P<0.05.