Table 4.

Subgroup odds ratios and 95% confidence intervals of venous thromboembolism by α–fibrinogen Thr312Ala genotype, LITE

			Odds ratio (95% C.I.) by genotype
Subgroup	Cases (n)	Controls (n)	TT (referent)	TA	AA	p-value*
Study
ARIC†	316	628	1.0	1.13 [0.85–1.51]	1.74 [1.02–2.94]	.116
CHS†	190	386	1.0	1.60 [1.10–2.32]	1.26 [0.68–2.32]	.048
Race
Black‡	135	268	1.0	1.50 [0.96–2.35]	1.05 [0.53–2.05]	.184
White‡	371	746	1.0	1.20 [0.92–1.56]	1.92 [1.16–3.18]	.028
Case subgroups
PE§	155	1014	1.0	1.04 [0.72–1.50]	1.85 [1.05–3.25]	.094
DVT§	421	1014	1.0	1.41 [1.11–1.79]	1.52 [1.00–2.33]	.0094
Both PE and DVT§	70	1014	1.0	1.56 [0.92–2.66]	2.55 [1.20–5.42]	.038
Idiopathic VTE§	218	1014	1.0	1.26 [0.92–1.72]	1.78 [1.06–2.97]	.062
Secondary VTE§	288	1014	1.0	1.29 [0.98–1.70]	1.29 [0.78–2.14]	.174

^*for a 2 degree of freedom test

^†adjusted for age, sex, race

^‡adjusted for age, sex, study

^§adjusted for age, sex, race, study