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. 2009 May 22;5(5):e1000491. doi: 10.1371/journal.pgen.1000491

Figure 5. Human microarray studies show consistent high-level expression of genes and pathways insertionally mutated in AKXD Lmo2 tumors.

Figure 5

A) Genes selectively expressed in LMO2-overexpressing patients from three human microarray analyses are shown. Below the first author citations are shown the number of patients in each study. The genes shown in red are retroviral insertions in the mouse Lmo2-clonal tumors. B) Select genes that were expressed in the LMO2-high class of patients were probed in the mouse tumors and are shown in the heat map. Several of these genes (e.g. Mef2c, Hhex, Syk, Lyn, Mycn) are differentially expressed in the mouse tumors in comparison to normal thymus and tumor 7065.