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Action potential frequency per synaptophysin density increases at an exponential rate. Spike frequency for neurons cultured in NbActiv4 (closed red symbols, R2 = 0.92, n = 3) increases exponentially as a function of synapses 1.97 times that in Neurobasal/B27 (open black symbols, R2 = 0.88, n = 3). The data are from figures 1 and 2 at developmental day 7 (circles), 14 (squares) and 21 (triangles).
