Figure 7.

Molecular modeling of interaction of 11b with tubulin. The image shows overlayered binding models of both 11b and colchicine with α,β-tubulin. The polypeptide backbone of α,β-tubulin is rendered as a wire model (light blue). The interactive residue side chains of α,β-tubulin that bind colchicine at the colchicine site are colored magenta in stick rendering. The 11b and colchicine atoms are also shown in stick rendering, with the carbon atoms of bound colchicine colored blue. The oxygen atoms of 11b are colored red and the carbon atoms of 11b are colored green. The black broken line identifies one potential intermolecular hydrogen bond between 11b and α,β-tubulin.