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. Author manuscript; available in PMC: 2009 May 8.
Published in final edited form as: Immunol Lett. 2007 Dec 26;117(1):57–62. doi: 10.1016/j.imlet.2007.11.018

Fig. 1.

Fig. 1

IL-24 modulates IFN-γ expression in ESAT-6 stimulated PBMC. (A) IFN-γ expression in PBMC from a TB patient is increased by exogenous IL-24 and IL-12 (40 ng/ml). Results are presented as the fold increase ± S.D. and are representative of individual experiments using PBMC from six different TB patients. **p < 0.01, Addition of IL-24 or IL-12 vs. medium. (B) IFN-γ expression in PBMC from an individual with LTBI is decreased by anti-IL-24 antibody (20 μg/ml). Results are presented as the fold increase ± S.D. and are representative of individual experiments using PBMC from three different individuals with LTBI. *p < 0.05, Addition of anti-IL-24 antibody vs. isotype control. (C and D) Messenger RNA expression of IFN-γ is consistent with production of IFN-γ protein. PBMC from TB patient was stimulated with ESAT-6 or PHA for either 15 h (mRNA) or 48 h (protein). Results are shown as the fold increase ± S.D. (mRNA) or pg/ml ± S.D. (protein) and are representative of individual experiments using PBMC from three different TB patients with similar results. (E and F) Messenger RNA expression of IL-24 is consistent with production of IL-24 protein. PBMC from TB patient was stimulated with ESAT-6 or PHA for either 15 h (mRNA) or 48 h (protein). Results are shown as the fold increase ± S.D. (mRNA) or pg/ml ± S.D. (protein) and are representative of individual experiments using PBMC from three different TB patients with similar results.