Table 5.

Biological functions of proteins differentially phosphorylated and glycosylated in samples from cells with versus without induced expression of wild-type α-Syn.

I. Proteins involved in translation and elongation Nucleophosmin Elongation factor 1β

II. Proteins involved in signal transduction 14-3-3

III. Proteins involved in turnover Ubiquitin carboxy-terminal hydrolase isozyme Transitional endoplasmic reticulum ATPase Proteasome subnit α 3

IV. Proteins involved in α-Syn induced changes in cellular energetics Glutathione S-transferase P Peroxiredoxin 2

V. Molecular chaperones modified due to α-Syn accumulation Heat shock 70kDa protein Heat shock protein HSP-90β Heat shock cognate 71 kDa protein 60 kDa heat shock protein, mitochondrial precursor T-complex protein 1subunit ε Endoplasmin precursor (HSP 90 beta member) Neutral alpha-glucosidase AB precursor

VI. Cytoskeletal proteins Actin

VII. Other proteins L-lactate dehydrogenase B chain Protein disulfide-isomerase A3 precursor