Figure 3.

Tissue distribution of liposome-complexed adenovirus in normal mice after systemic administration. (A) Luciferase expression in liver following systemic administration of adenoviruses. 1 × 10¹¹ vp of Ad-luc or Ad-luc/PEGPE was injected intravenously and transgene expression was measured after 24 h. Liver was harvested, homogenized and then luciferase activity was measured using the kit according to the manufacturer's instructions. Each data represents the mean ± S.D. (n = 5). (B) Tissue distribution of luciferase expression following systemic administration of adenoviruses. 1 × 10¹¹ vp of Ad-luc or Ad-luc/PEGPE was intravenously injected into the Balb/c mice and luciferase expression was measured in each tissue. Luciferase activity in each tissue was calculated relative that in the liver. The data represent the mean ± S.D.