Figure 1.

The ACAT inhibitor OAA promotes spontaneous cholesterol efflux from THP-1, cultured macrophages. (A) The structure of OAA. Whole-cell ACAT activity (B) and cholesterol efflux (C) in THP-1, cultured macrophages were determined. ACAT activity was measured by determining the incorporation of [¹⁴C]oleoyl-CoA into labeled cholesteryl oleate. The values shown are expressed as the percentage inhibition of ACAT activity in control incubations. The cholesterol efflux are expressed as the percentage of total cellular [¹⁴C]cholesterol. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus acLDL-loaded cells.