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. 2009 Jan 31;41(1):42–50. doi: 10.3858/emm.2009.41.1.006

Figure 1.

Figure 1

(A) Overall structure of Dg3 and ΔNDg3. EC1-EC4, four extracellular cadherin-typical repeats; EA, extracellular anchor domain; TM, transmembrane domain; IA, intracellular anchor domain; ICS, intracellular cadherin-specific domain; IPL, proline-rich linker domain; RUD, repeating unit domain; DTD, desmoglein-specific terminal domain. ΔNDg3 contains slightly shorter ICS, IPL, RUD and DTD domains. (B) Northern blot analysis. HaCaT cells were treated with 1 µM A23187 and 0.3 mM calcium for the indicated time points. About 5.6 kb Dg3 mRNA and 4.6 kb ΔNDg3 mRNA were shown. Cyclophilin was detected as a loading control.