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TrkA overexpression induces γH2AX production and PARP cleavage. (A) U2OS-TrkA-67 cells were uninduced or induced with tetracycline for the indicated times followed by Western blot analysis. The arrow in the second panel indicates the cleaved product of PARP. (B) U2OS-TrkA-67 cells were uninduced or induced with tetracycline for 24 h and then untreated or treated with K-252a (0.5 µgM), GW441756 (0.5 µgM), or doxorubicin (1 µg/ml) for 4 h followed by Western blot analysis.
