Table 4.

Regression analysis of ERI in hemodialysis patients according to the ACE I/D, IL-1B-511C/T polymorphisms and combinations of alleles of two loci.

ERI, erythropoietin resistance index; C, combination

^*C/C, C/R and R/R represent homozygotes for the common allele, heterozygotes and homozygotes for the rarer allele, respectively.

^aMean ± standard deviation of ERI (IU/kg weight/g Hb).

Pa, Pb and Pc are P values of codominant (minor allele homozygotes vs. heterozygotes vs. major allele homozygotes), dominant (minor allele homozygotes plus heterozygotes vs. major allele homozygotes) and recessive (minor allele homozygotes vs. heterozygotes plus major allele homozygotes) models for multiple regression analysis controlling for age, sex, time on dialysis, ACE inhibitor or ARB use, ferritin, transferrin saturation, intact PTH, hs-CRP, albumin, Kt/V and presence of diabetes mellitus as covariates.