Figure 4.

Effect of Lipo-HNK on tumor growth and survival of tumor-bearing mice. There were ten mice in each group. The five groups of tumor-bearing mice were treated with i.p. axenic NS (◆) (0.5 ml each), Lipo-HNK (▲) at 25 mg/kg, Lipo-null (□) at 37.5 mg/kg for 10 days, and RT (△) (5 Gy each) for 5 days. The combination group (■) was treated with a dose of 5 Gy/day for five days after treatment with Lipo-HNK for 40 min, followed by continued treatment with Lipo-HNK for five days. Mice were inoculated s.c. in the right posterior limb with LL/2 cells. (A) Inhibition of tumor growth in mice. Combination therapy resulting in significant tumor growth inhibition versus NS controls (P < 0.01); There was no difference between NS and the Lipo-null control (P > 0.05). (B) A significant increase in survival in the combination treated mice, compared with the NS control (P < 0.05, by log-rank test), was found. Data are expressed as mean ± SD. ^*P < 0.05 vs. control (NS). ^**P < 0.01 vs. control (NS).