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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Annu Rev Pathol. 2009;4:287–313. doi: 10.1146/annurev.pathol.4.110807.092246

Figure 5. Genetically engineered mouse models of ovarian cancer recapitulate their human counterparts and respond to molecularly-targeted therapeutics.

Figure 5

A) Hematoxylin & eosin stained section of endometrioid carcinoma-like mouse tumor. B) Representative ovarian carcinoma in right ovary of Apcflox/flox;Ptenflox/flox mouse 11 wks after ovarian bursal injection of adenovirus expressing Cre recombinase (AdCre). C) Rapamycin inhibits tumor growth. Animals with small ovarian carcinomas (6 wks after AdCre injection) were treated twice weekly for 4 wks with vehicle or two different doses of rapamycin. D) Representative ovarian carcinoma in right ovary after 4 wks of treatment with rapamycin.