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. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):8158–8162. doi: 10.1021/jm801254r

Figure 6.

Figure 6

Induction of cIAP-1 degradation, cleavage of PARP and processing of caspase-3 by compounds 1, 2, 4 and 6 in the MDA-MB-231 cell line. Cells were treated with different concentrations of Smac mimetics for 24 hours and levels of cIAP-1, cleaved PAPR (CL PARP), cleaved caspase-3 (CL C3) were probed by Western blot.