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VH (A) and JH (B) gene family usage profiles of cancer-derived Ig compared with the normal PBL-derived Ig. We analyzed the usage of 78 functional VH genes from the cancer-derived Ig and collected five groups of usage profiles from healthy donors PBL-derived Ig from previous studies (22, 23, 25, 26, 33). The VH and JH gene family usage data from the combined patient group differed significantly from that of the healthy donors PBL-derived Ig (p < 0.05 for both VH and JH).
