TABLE 1.
Rate of functional rearrangement in 89 VHDJH recombinations from different cancer types
| Sample origin | Ig type | No. of sample | No. of clone | No. of functional VHDJH recombination | No. of non-functional VHDJH recombination | |
|---|---|---|---|---|---|---|
| PBL | γ chain | 2 | 6 | 5 | 1 | |
| μ chain | 2 | 4 | 4 | 0 | ||
| Total | 4 | 10 | 9 | 1 (10%)a | ||
| Breast cancer | γ chain | 3 | 12 | 10 | 2 | |
| μ chain | 3 | 10 | 10 | 0 | ||
| Lung cancer | γ chain | 1 | 6 | 6 | 0 | |
| μ chain | 1 | 2 | 2 | 0 | ||
| Colon cancer | γ chain | 2 | 11 | 10 | 1 | |
| μ chain | 1 | 5 | 4 | 1 | ||
| Oral carcinoma | γ chain | 2 | 12 | 10 | 2 | |
| μ chain | 1 | 9 | 7 | 2 | ||
| HT29 cell | γ chain | 1 | 7 | 7 | 0 | |
| μ chain | 1 | 6 | 5 | 1 | ||
| Hela S3 cell | γ chain | 1 | 6 | 4 | 2 | |
| μ chain | 1 | 3 | 3 | 0 | ||
| Total (cancer) | 18 | 89 | 78 | 11 (12%) | ||
a
The percentage of all sequences corresponding to each group of genes is shown in parentheses