TABLE 2.

Interactions between LGP2 CTD and the 8-bp dsRNA

HB, hydrogen bonds; VDW, van der Waals' contacts; HP, hydrophobic interactions; sHB, solvent mediated hydrogen bonds. The solvent distances to dsRNA atoms and protein atoms are shown. ES, electrostatic interactions.

Nucleotide (ends) atoms	LGP2 CTD atoms	Distances	Type of interactions
		Å
G1 (5′)
C-1′	Val595 CG1	3.62	HP
O-6	Ile597 CG2	3.64	HP
N-2	Trp604 CH2	3.69	VDW
O-2′	Leu621 CB	3.18	VDW
N-7	Val596 O	2.99/3.30	sHB
C2 (5′)
O-2′	His576 ND1	2.83	HB
O-2P	Gly620 CA	3.40	VDW
O-4′	Leu621 CD2	3.51	VDW
C-4′	Val632 CG1	3.72	VDW
O-1P	Lys634 NZ	3.98	ES
O-2′	His577 N	2.92/2.78	sHB
O-3′	Leu633 O	3.25/2.73	sHB
G3 (5′)
O-2′	Thr575 CB	3.35	VDW
O-2P	Lys634 NZ	3.53	ES
O-1P	Val635 N	3.05	HB
O-1P	Trp652 N	2.79/2.96	sHB
O-3′	Thr575 O	2.96/2.89	sHB
C4 (5)
O-2P	Lys651 CB	3.64	VDW
O-2P	Trp652 N	3.58	HB
O-2P	Ser653 OG	2.54	HB
O-2P	Ser653 N	2.95	HB
O-1P	Trp652 N	2.74/2.96	sHB
G5 (5′)
O-2P	Lys651 NZ	2.96	ES
O-1P	Arg654 NH2	3.24	ES
C6 (5)
O-1P	Arg654 NH2	2.64/3.15	sHB
G1 (3′)
C-8	Arg636 NH1	3.39	VDW
O-5′	Arg636 NH1	3.51/2.94	sHB
G7 (3′)
N-2	His576 CE1	3.91	VDW
O-2P	Lys599 NZ	3.88	ES
C8 (3′)
O-2′	Glu573 OE2	2.50	HB
O-3′	Glu573 OE1	2.73	HB
O-2′	His576 NE2	2.87	HB
N-4	Lys599 CD	3.73	VDW
N-3	Phe601 CZ	3.46	HP
O-2′	Trp604 NE1	3.03	HB
O-3′	Lys602 N	2.81/2.82	sHB