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. 1999 Mar 2;96(5):2396–2401. doi: 10.1073/pnas.96.5.2396

Figure 1.

Figure 1

SipB dependence of the cytotoxicity of Salmonella on the J774A.1 macrophage cell line. Cells were infected at an moi of 100:1 for 10 hr and then processed for a LDH-release assay. The wild-type S. typhi (WT) was cytotoxic to J774A.1 cells. An insertion mutant of sipB (SipB-) did not retain the cytotoxic phenotype, which can be complemented by sipB in trans (SipB−/pFSipB). The negative control (SipB−/pUC19) did not restore the killing activity. The means and standard deviations of three experiments are shown.