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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2009 Mar 3;8(3):703–710. doi: 10.1158/1535-7163.MCT-08-0656

Figure 1.

Figure 1

48 hr iso-surface snap of SPECT-CT images comparing K562 tumor-bearing nude mice injected with 111In-EC-BSA or 111In-EC-APT before and after 5 days of imatinib treatment. Images were fused together using the Amira software, which allows visualization of bony structures in three dimensions. Left panel imaged with 111In-EC-BSA shows baseline levels of blood flow to the tumor (right leg). Middle panel imaged with 111In-EC-APT detects the phosphokinase. Right panel imaged with 111In-EC-APT after 5 days of imatinib shows down-regulation of the phosphokinase. Previous experiments have shown that radiolabeled isotypic control antibody does not image (8).