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Rac1 is overexpressed in AIDS-KS, mECK36 (KSHV-mKS), and RacCA-mKS tumors. Immunofluorescence detection of Rac1 and KSHV LANA expression in AIDS-KS tumor biopsies (A), KSHV-mKS (mECK36 tumors) (C), and RacCA tumors (D) compared with normal human skin tissue (B) and mouse skin tissue (D).