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. Author manuscript; available in PMC: 2009 May 8.
Published in final edited form as: Tumour Biol. 2008 Jul 9;29(3):161–180. doi: 10.1159/000143402

Figure 12. Levels of therapy for cancer.

Figure 12

Radiation therapy and chemotherapy kill proliferating transit amplifying cells of a cancer. Anti-angiogenic therapy inhibits the blood supply to the proliferating cells. Differentiation therapy reverses maturation arrest and allows proliferating cancer cells to terminally differentiate. Even if these approaches are successful, cancers may re-grow from cancer stem cells that are not affected by these therapies. It is hypothesized that cancer stem cell inhibition therapy would block the proliferation of cancer stem cells and prevent re-growth [188].