Table 3.

List of the top ten significant reporter metabolite and subsystem scores for the gdh1/GDH2 vs. wild type comparison in aerobic conditions.

Reporter metabolite	Z-score	No of reactions*
L-proline [c]	2.71	4
Carbon dioxide [m]	2.51	15
Proton [m]	2.19	51
Glyceraldehyde 3-phosphate [c]	1.93	7
Ubiquinone-6 [m]	1.82	5
Ubiquinol-6 [m]	1.82	5
Ribulose-5-phosphate [c]	1.80	4
Uracil [c]	1.74	4
L-homoserine [c]	1.72	4
Alpha-ketoglutarate [m]	1.71	8
Reporter subsystem	Z-score	No of reactions
Citric Acid Cycle	4.58	7
Pentose Phosphate Pathway	3.29	12
Glycine and Serine Metabolism	2.69	17
Alanine and Aspartate Metabolism	2.65	6
Oxidative Phosphorylation	1.79	8
Thiamine Metabolism	1.54	8
Arginine and Proline Metabolism	1.44	20
Other Amino Acid Metabolism	1.28	5
Glycolysis/Gluconeogenesis	0.58	14
Anaplerotic reactions	0.19	9

*Number of reactions categorized in a subsystem or found to be neighboring each metabolite