Table 3.

Hematological values, clinical biochemical findings, and organ weights in SD rats after weekly injection of rhArg1-peg_{5,000 mw} for 4 weeks.

Parameters	Control	15,000 U/kg	50,000 U/kg
Hematological values
RBC (× 1012/l)	8.25 ± 0.87	8.91 ± 0.90	8.20 ± 0.89
WBC (× 109/l)	5.27 ± 1.14	5.68 ± 1.08	4.02 ± 0.71*
Hb (g/l)	136.33 ± 17.25	134.50 ± 6.83	122.33 ± 6.80
MCH (pg)	16.50 ± 1.05	15.23 ± 1.67	15.00 ± 1.12*
MCHC (g/l)	342.00 ± 13.31	287.17 ± 35.82**	305.17 ± 19.26**
PLT (× 109/l)	742.50 ± 156.23	663.00 ± 121.51	545.83 ± 113.26*
HCT (%)	0.399 ± 0.05	0.474 ± 0.06*	0.403 ± 0.039
MCV (fl)	48.33 ± 2.25	53.18 ± 4.03*	49.17 ± 0.96
Clinical biochemical findings
ALT (nmol/l)	818.50 ± 69.16	796.83 ± 110.52	733.48 ± 118.66
CK (μmol/l)	112.60 ± 37.41	88.30 ± 27.17	88.14 ± 24.33
CH (mmol/l)	3.219 ± 0.51	2.500 ± 0.6**	2.879 ± 0.639
AST (nmol/l)	2883.90 ± 602.99	2622.20 ± 420.55	2300.46 ± 512.72
ALB (g/l)	42.60 ± 8.38	40.10 ± 18.83	35.86 ± 5.46
TP (g/l)	86.70 ± 12.49	76.20 ± 10.25	84.86 ± 15.08
BUN (mmol/l)	7.919 ± 3.267	9.305 ± 1.200	9.801 ± 0.815
TG (mmol/l)	3.129 ± 1.087	2.672 ± 1.175	2.832 ± 0.112
Organ weights (g)
Brain	0.380 ± 0.063	0.345 ± 0.050	0.324 ± 0.031*
Gland	0.071 ± 0.026	0.080 ± 0.037	0.074 ± 0.023
Heart	0.184 ± 0.021	0.180 ± 0.031	0.195 ± 0.020
Lung	0.237 ± 0.040	0.216 ± 0.051	0.233 ± 0.038

Notes: All values are expressed as mean ± standard deviation. RBC, red blood cell count; WBC, white blood cell count; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PLT, platelet count; HCT, hematocrit; MCV, mean corpuscular volume; ALT, alanine aminotransferase; CK, creatine kinase; CH, cholesterol; AST, aspartate aminotransferase; ALB, albumin; TP, total plasma protein; BUN, urea nitrogen in blood; and TG, triglycerides. Significant differences as compared with control by Duncan's t-test after ANOVA test (*p < 0.05; **p < 0.01).