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CYT-IVAC vaccination significantly reduces viral loads in lung tissue following lethal challenge. Mice vaccinated with either wild-type vaccine or CYT-IVACs challenged on day 35 post-vaccination with 100 LD50 of mouse-adapted A/PR/8/34. Mice were sacrificed on day 4 post-challenge and viral loads from homogenized lung tissue (n = 3) were determined by tissue culture infectious dose assay. Data is expressed as TCID50 per gram of lung tissue. (* p < 0.05 compared to PR/8/34 w.t.)
