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. 2009 Apr-Jun;3(2):224–229. doi: 10.4161/cam.3.2.7766

Table 1.

Examples of polymeric systems designed for brain delivery of antiangiogenesis compounds

Technique of delivery Antiangiogenic factor Polymer Reference
Cell encapsulation Endostatin, Interferon-□, Angiostatin Alginate/PLL 59–62
Non-viral gene therapy interleukin-12 PPC 64, 65
Biodegradable matrices/Nano/micro particles PEX, PF4/CTF, heparin minocycline, PLGA, pCPP:SA, PEG 54–56
Polymer conjugations/ interferon alpha, HPMA, 82, 83, 87
Polymeric micelles TNP-470 mPEG-PLA
*

This list is partial and includes only direct antiangiogenic factors studied in brain tumors. PLL, Poly L-lysine; PLGA, Poly-(lactic-co-glycolic)acid; pCPP:SA, poly[bis(p-carboxyphenoxy)propane-sebacic acid]; PPC, polyethylenimine—methoxypolyethyleneglycol and cholesterol; PEG, Polyethylene glycol.