Table 1.

Diagnostic accuracies of urine analytes and proteomic scores for predicting need for delivery in the cross-sectional challenge phase.

Analytes	ROC area [95%CI]	P value	Cut-off*	Sens. [95%CI]	Spec. [95%CI]	+LR	−LR	Accuracy
Protein-to-creatinine ratio (mg/mgc)	0.51 [0.43–0.58]	0.901	> 8.4	52 [41–63]	59 [49–68]	1.3	0.8	55.9
sFlt-1-to-creatinine ratio (pg/mgc)	0.71 [0.64–0.78]	<0.001	>28.0	63 [52–73]	72 [62–80]	2.2	0.5	67.7
PlGF-to-creatinine ratio (pg/mgc)	0.77 [0.71–0.83]	<0.001	< 57.6	85 [75–92]	67 [57–76]	2.6	0.2	74.5
sFlt-1-to-PlGF ratio	0.82 [0.75–0.87]	<0.001	> 1.3	88 [79–94]	69 [59–77]	2.8	0.2	77.1
UPSb	0.92 [0.87–0.95]	<0.001	≥ 5	85 [76–92]	86 [79–92]	6.2	0.2	85.7
UPSr	0.92 [0.87–0.96]	<0.001	≥ 7	84 [74–91]	89 [82–94]	7.7	0.2	86.7
Non-reassuring urine profile: UPSb ≥5 and UPSr ≥7				85 [77–93]	87 [81–96]	6.7	0.2	86.2

^*represents the cut-off with highest accuracy.

Abbreviations: Sens: sensitivity; Spec: specificity; +LR: positive likelihood ratio; −LR: negative likelihood ratio; mgc: milligrams creatinine; sFlt-1: soluble fms-like tyrosine kinase-1; PlGF: placental growth factor