Table 3. Angiogenic Factor Concentrations at 10-20, 21-32, and 33-42 Weeks of Gestation in Normotensive Controls and in Women Who Subsequently Developed Proteinuria Documented either by Dipstick or by 24-hour Urine or Protein/Creatinine Ratio.

10-20 wks	Control	GP by Dipstick	GP by 24 Hr Urine or P/C Ratio
N	1353	79	19
GA at collection (days)	114 ± 19	113 ± 19	116 ± 21
sFlt-1 (pg/ml)	3786 ± 1989	3368 ± 1814	3636 ± 2074
PlGF (pg/ml)	146 ± 126	115 ± 72*	163 ± 151
sEng (ng/ml)	5.6 ± 5.4	5.0 ± 1.0	5.30 ± 1.13
21-32 wks
N	1363	65	15
GA at collection (days)	192 ± 11	194 ± 11	194 ± 11
sFlt-1 (pg/ml)	4005 ± 2356	3769 ± 2078	4391 ± 2901
PlGF (pg/ml)	733 ± 621	591 ± 455	496 ± 198
sEng (ng/ml)	5.5 ± 7.6	5.3 ± 2.1	5.5 ± 1.5
33-42 wks
N	1217	43	6
GA at collection (days)	255 ± 6	257 ± 9	256 ± 7
sFlt-1 (pg/ml)	7823 ± 4725	9450 ± 6086*	10108 ± 3524*
PlGF (pg/ml)	583 ± 697	384 ± 436*	170 ± 66*
sEng (ng/ml)	10.2 ± 7.9	11.8 ± 8.7	15.2 ± 6.6**

Data is presented as N for number of specimens or arithmetic mean ± s.d.

GA = gestational age GP = gestational proteinuria

sFlt-1 = soluble fms-like tyrosine kinase 1 PlGF = placental growth factor sEng = soluble endoglin

Comparisons of angiogenic factor concentrations used logarithmically transformed values.

^*P <0.05,

^**P <0.01

^***P < 0.001 for comparisons with controls after adjusting for BMI, race/ethnicity, and GA at collection

There were no significant differences in angiogenic factor concentrations between GP by dipstick and GP by 24-hour urine or P/C ratio