TABLE 4.
Odds ratios for breast cancer according to quintile of serum phospholipid cis- and trans-fatty acids (% of total fatty acids) in the E3N-EPIC Study (363 cases, 702 controls), France, 1995–1998
| Quintile of serum fatty acids |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 (referent) (OR*=1) | 2 | 3 | 4 | 5 | p-trend | |||||
| OR† | 95% CI* | OR† | 95% CI* | OR † | 95% CI* | OR† | 95% CI* | |||
| cis- and trans-MUFAs* | ||||||||||
| cis-16:1n-7, cis palmitoleic acid | 1 | 0.82 | 0.54, 1.26 | 1.22 | 0.80, 1.85 | 1.00 | 0.64, 1.56 | 1.06 | 0.67, 1.68 | 0.61 |
| cis 18:1n-9, oleic acid | 0.87 | 0.56, 1.36 | 1.46 | 0.95, 2.26 | 0.74 | 0.48, 1.15 | 1.18 | 0.77, 1.81 | 0.65 | |
| trans-16:1n-7, trans-palmitoleic acid | 1 | 0.88 | 0.58, 1.33 | 1.17 | 0.74, 1.83 | 1.49 | 0.93, 2.40 | 2.24 | 1.30, 3.86 | 0.002 |
| trans-18:1n-9, elaidic acid | 1 | 1.14 | 0.73, 1.78 | 1.02 | 0.63, 1.64 | 1.04 | 0.64, 1.69 | 1.45 | 0.90, 2.33 | 0.12 |
| trans-MUFAs, 16:1n-7 þ 18:1n-9 | 1 | 1.23 | 0.79, 1.93 | 1.12 | 0.71, 1.78 | 1.54 | 0.97, 2.45 | 1.75 | 1.08,2.83 | 0.018 |
| cis- and trans-linoleic acid | ||||||||||
| cis- 18:2n-6, cis- linoleic acid | 1 | 1.26 | 0.83, 1.93 | 1.51 | 0.98, 2.33 | 1.11 | 0.72, 1.71 | 1.05 | 0.67, 1.64 | 0.89 |
| trans-18:2n-6, trans-linoleic acid | 1 | 1.02 | 0.58, 1.77 | 1.07 | 0.63, 1.84 | 1.13 | 0.66, 1.94 | 1.55 | 0.91,2.63 | 0.10 |
*
OR, odds ratio; CI, confidence interval; MUFAs, monounsaturated fatty acids.
†
Adjusted for body mass index, alcohol consumption, height, menopausal hormone use, educational level, parity, family history of breast cancer, and history of benign breast disease.