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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8416–8424. doi: 10.4049/jimmunol.181.12.8416

Figure 3. The two DH frameshift mutations flip the usage ratio of RF1 versus RF2.

Figure 3

The percent usage of RF1 and RF2 among unique, in-frame Igμ transcripts with recognizable DFL16.1 sequence from Hardy fractions B (CD19+ CD43+ IgM− BP-1−), C (CD19+ CD43+ IgM− BP-1+), D (CD19+ CD43− IgM− IgD−), E (CD19+ CD43− IgM+ IgD−), and F (CD19+ CD43− IgMlo IgDhi) from wild type, ΔD-DFL, and ΔD-DμFS mice is displayed. When compared to ΔD-DFL and wild type controls, the use of hydrophobic and neutral DH reading frames has been flipped in B lineage cells from ΔD-DμFS mice.