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. Author manuscript; available in PMC: 2009 May 11.
Published in final edited form as: Stroke. 2008 Dec 8;40(3 Suppl):S16–S19. doi: 10.1161/STROKEAHA.108.533174

Figure 1. Severely impaired vasodilation in CAA-affected vessels.

Figure 1

Live images of the leptomeningeal arterioles of a 12 month-old Tg2576 mouse brain were taken before (baseline) and 4 min after induced hypercapnia. Methoxy-X04-positive CAA deposits were imaged in the same vessel. Hypercapnia-induced vasodilation was noted in vessel segments without CAA (arrowheads), while minimal vascular response was noted in vessel segments with CAA (arrows), as determined by vessel caliber. Scale bar: 100 µm.