Table 1.

Progression of CAA

	Elevated soluble Aβ	Early CAA	Moderate CAA	Advanced CAA	Dyshoric vessels
Vascular Pathology	None	None	Altered VSMC architecture	Amyloid replacement of VSMCs	Fibrinoid necrosis, microaneurysms
Cell death	None	None	VSMCs (early loss)	VSMCs (severe loss)	VSMCs, CECs, pericytes
Vascular Function	Impaired reactivity (moderate)	Impaired reactivity (severe)	Absent reactivity	Absent reactivity	Absent reactivity
Brain Pathology	None	White matter disease and cortical infarcts			Frank hemorrhage
Clinical	?	Cognitive dysfunction?			Major M&M

VSMCs, vascular smooth muscle cells

CECs, cerebral endothelial cells