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. 2009 May 19;4(5):e5597. doi: 10.1371/journal.pone.0005597

Figure 1. NKG2D-mediated killing directly correlates with the strength of NKG2D expression.

Figure 1

Killing rates of C1R cells transfected with an empty vector (C1R/Mock, gray bars) or with the NKG2D-ligand ULBP1 (C1R/ULBP1, black bars) by a representative bulk NK culture NK-A.K. Effector-to-target ratio was 5∶1. ** indicates P value<0.01. (B) NKG2D staining phenotype on a representative bulk NK culture NK-A.K. (C) Correlation between NKG2D expression (X-axis) and percent specific killing via NKG2D (Y-axis). FAB stands for fold above background, which is the ratio between specific and background staining intensity. The percent specific killing via NKG2D is the difference between killing of C1R/ULBP1 to C1R/Mock by the effector cells. Each black square represents the mean values of a different NK bulk culture tested three times. Correlation was tested statistically with Spearman's correlation.