Table 3.
Combined GSTT1 and GSTM1 genotype frequencies and their associations with risk of SGC
| Combined genotypes | SGC (n = 166) | Controls (n = 511) | pa | Crude OR (95% CI) | Adjusted ORb (95% CI) | ||
|---|---|---|---|---|---|---|---|
| N | % | N | % | ||||
| Both wild typec(ref.) | 55 | 33.0 | 189 | 37.0 | 0.176 | Reference | Reference |
| T1 wild type/M1 null | 65 | 39.2 | 217 | 42.5 | 1.0 (0.7 – 1.5) | 1.0 (0.6 – 1.4) | |
| T1 null/M1 wild type | 23 | 13.9 | 62 | 12.1 | 1.3 (0.7 – 2.2) | 1.2 (0.6 – 2.1) | |
| Both null | 23 | 13.9 | 43 | 8.4 | 1.8 (1.0 – 3.3) | 1.9 (1.0 – 3.5) | |
| Trend test | 0.050 | 0.061 | |||||
a
Chi-square analysis comparing genotype distributions and polymorphic allele frequencies between case subjects and control subjects;
b
adjusted for age, sex, ethnicity, tobacco use, family history of cancer, alcohol use and radiation exposure. Family cancer history unavailable for 11 control subjects and radiation exposure data unavailable for 13 control subjects;
c
Ref.=reference group