Figure 1 Pedigree of an amyotrophic lateral sclerosis (ALS) family with a SOD1 mutation

The pedigree structure of the Filipino family segregating the ΔG27/P28 mutation (del); the asterisk indicates the 12 individuals for whom DNA samples and genotypes were obtained. Affected individuals are shown as filled symbols and the arrow points to the proband with the homozygous deletion. A slash indicates deceased persons. Below the DNA number is the age at onset for affected individuals, age at examination, or age at death for unaffected individuals. Genotypes are shown only for the key individuals to protect family confidentiality. Markers used for haplotype analysis are shown to the left (founder haplotype is in bold). The inferred haplotype of the proband's father (no. 3) is reconstructed based on the genotypes of his four children available for study.