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Figure 5 Immunohistochemical labeling in motor neurons of the homozygous mutation carrier
Labeling of hyaline conglomerate inclusions (HCI) in patient 1078 carrying the homozygous ΔG27/P28 SOD1 mutation show specificity for SOD1-related amyotrophic lateral sclerosis. Hematoxylin staining (A) shows floccular appearance of HCI. Labeling of HCIs with phosphorylated neurofilament antibody (B) and an antibody recognizing misfolded SOD1, SEDI antibody (C). Scale bar = 12 μm.
