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. Author manuscript; available in PMC: 2009 Jul 4.
Published in final edited form as: Neurosci Lett. 2008 May 2;439(1):100–105. doi: 10.1016/j.neulet.2008.04.096

Figure 3. Hippocampal and cortical structures in single and compound Pafah1b1;Dab1 heterozygous mice.

Figure 3

Sagittal sections of the hippocampus were obtained from adult mice of the indicated genotype and were stained with cresyl violet (A–D). Neocortical sections from the same mice were processed for immunohistochemistry using Calbindin antibodies (E–H). Single heterozygous Dab1 mice are phenotypically normal as they exhibit compact cellular layers in the hippocampus (A) and Calbidin-positive cortical neurons correctly positioned mostly in upper layers (E). Single heterozygous Pafah1b1 mice exhibit a modest split in the hippocampal pyramidal layer (B) but normal-appearing cortical layers (F). Double heterozygous Pafah1b1;Dab1 exhibit enhanced disruption of hippocampal (C) and cortical (G) layers. Triple mutants (D and H) also carrying a mutation in Pafah1b2 appeared similar to double mutants. Scale bar = 500μm.