Table 5.
Auto-immune Thyroid Disease Replication Results
| Gene | SNP | Replication Cohort | Combined Cohort | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Case MAF | Control MAF | OR | p val | Case MAF | Control MAF | OR | p val | ||
|
| |||||||||
| FCRL3 | rs3761959* | 0.48 | 0.45 | 0.90 | 0.029 | 0.49 | 0.45 | 0.87 | 9.4×10-3 |
| FCRL3 | rs11264794 | 0.42 | 0.46 | 1.10 | 0.079 | 0.42 | 0.46 | 1.12 | 0.013 |
| FCRL3 | rs11264793 | 0.27 | 0.24 | 0.87 | 0.020 | 0.26 | 0.24 | 0.90 | 0.044 |
| FCRL3 | rs11264798 | 0.44 | 0.49 | 1.21 | 4.0×10-3 | 0.44 | 0.49 | 1.22 | 1.6×10-5 |
| FCRL3 | rs10489678 | 0.19 | 0.20 | 1.07 | 0.30 | 0.20 | 0.20 | 1.04 | 0.43 |
| FCRL3 | rs6691569 | 0.28 | 0.28 | 1.03 | 0.60 | 0.29 | 0.29 | 1.00 | 0.93 |
| FCRL3 | rs2282284 | 0.062 | 0.058 | 0.92 | 0.013 | 0.062 | 0.058 | 0.93 | 0.47 |
| FCRL5 | rs6667109 | 0.17 | 0.15 | 0.91 | 0.18 | 0.18 | 0.15 | 0.85 | 7.7×10-2 |
*
This SNP tags the SNP rs7522061 which was flagged as associated with AITD in the WTCCC screen (p = 2.1 × 10-4)