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. Author manuscript; available in PMC: 2009 May 11.
Published in final edited form as: Chem Biol Drug Des. 2008 Sep;72(3):171–181. doi: 10.1111/j.1747-0285.2008.00698.x

Table 2.

Activity[a] of yPFTase in the presence of compounds 5 and 9.

Substrate Enzyme activity (μM/min) Normalized activity (%)
FPP 0.765 ± 0.007 100
Compound 5 0.104 ± 0.006 14
Irradiated Compound 5 0.681 ± 0.012 89
Compound 9 0.058 ± 0.001 7.6
Irradiated Compound 9 0.557 ± 0.006 73
[a]

When present, FPP and/or caged FPP were each at 10 μM. Given the rate of photolysis, the irradiated samples would be expected to contain 10 μM free FPP and side products. The CAAX peptide substrate is N-Dansyl-GCVIA