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. Author manuscript; available in PMC: 2009 May 11.
Published in final edited form as: Cell. 2008 Jan 25;132(2):208–220. doi: 10.1016/j.cell.2007.12.029

Figure 3. The IS608 Right End is Directed into the TnpA Active Site by Internal DNA Interactions, not by Protein-DNA Recognition.

Figure 3

(A) Overall view of theTnpA/RE35 structure. (B) Close-up of the active site showing the base pairs between the four bases at the RE of IS608 (TCAA) and bases 5′ of IPRE (GAAT) from base G−35 to T−32, in light blue). The grey sphere is bound Mn2+. (C) Two base triplets (top) are central to the RE35 conformation (shown in two orthogonal views in the middle and bottom panels).