TABLE II.
Mean integrated gray values/100 presented as arbitrary units
| Experimental group means (± SEM) |
||||||
|---|---|---|---|---|---|---|
| Brain region | Naive | Acute | Chronic | |||
| Forebrain | ||||||
| Nucleus accumbens* | 15 | (7.3) | 133† | (29) | 44 | (9.0) |
| Anterior BNST* | 1.3 | (0.3) | 32† | (11) | 4.4 | (0.6) |
| Caudate nucleus dorsal | 21 | (3.9) | 69 | (18) | 67 | (12) |
| Caudate nucleus ventral | 9.3 | (3.2) | 13 | (2.9) | 12 | (1.6) |
| Medial septum | 3.8 | (1.3) | 7.4 | (1.1) | 4.3 | (0.6) |
| Lateral septum* | 2.6 | (0.4) | 203† | (66) | 55 | (12) |
| Septohypothalamic nucleus | 2.0 | (0.5) | 107 | (52) | 13 | (2.7) |
| Amygdala | ||||||
| Anterior cortical nuclei | 96 | (8.8) | 109 | (9.4) | 112 | (15) |
| Basolateral nucleus | 43 | (6.7) | 80 | (11) | 48 | (8.4) |
| Basomedial nucleus* | 14 | (2.0) | 37‡ | (3.6) | 28‡ | (5.1) |
| Central nucleus | 28 | (3.9) | 40 | (4.9) | 28 | (5.0) |
| Lateral nucleus* | 22 | (4.6) | 114† | (13) | 32 | (2.9) |
| Medial nucleus* | 25 | (3.8) | 64‡ | (7.9) | 43 | (5.9) |
| Hippocampus | ||||||
| Dentate gyrus* | 45 | (4.1) | 80‡ | (8.4) | 90‡ | (9.5) |
| CA1* | 31 | (4.5) | 89‡ | (11) | 57 | (9.0) |
| CA3 | 71 | (12) | 105 | (9.1) | 97 | (12) |
| Cortex | ||||||
| Cingulate* | 77 | (15) | 560‡ | (60) | 421‡ | (121) |
| Infralimbic* | 22 | (3.8) | 106† | (10) | 59 | (14) |
| Insular | 112 | (24) | 174 | (49) | 133 | (34) |
| Orbitofrontal* | 102 | (20) | 329† | (39) | 617¶ | (64) |
| Parietal | 487 | (150) | 711 | (256) | 591 | (219) |
| Piriform | 399 | (65) | 575 | (85) | 565 | (46) |
| Sensory | 1455 | (377) | 2071 | (612) | 1943 | (582) |
| Temporal (Auditory)* | 1530 | (273) | 4011† | (252) | 2140 | (412) |
| Hypothalamus | ||||||
| Anterior area* | 18 | (4.3) | 147‡ | (23) | 115‡ | (14) |
| Arcuate nucleus | 96 | (11) | 86 | (15) | 124 | (15) |
| Dorsomedial nucleus* | 60 | (13) | 312‡ | (65) | 207 | (29) |
| Lateral nucleus* | 21 | (4.6) | 65‡ | (14) | 60‡ | (9.3) |
| Lateral preoptic area* | 1.7 | (0.3) | 14‡ | (3.4) | 9.3 | (2.4) |
| Medial preoptic area* | 1.8 | (0.3) | 79‡ | (24) | 28 | (5.9) |
| Medial preoptic nucleus* | 1.3 | (0.4) | 12† | (2.4) | 5.3 | (0.7) |
| Paraventricular nucleus* | 3.2 | (0.7) | 61† | (24) | 11 | (1.9) |
| Posterior area* | 33 | (6.8) | 151‡ | (10) | 106‡ | (21) |
| Suprachiasmatic nucleus* | 74 | (9.0) | 37‡ | (7.2) | 45 | (8.6) |
| Supramammillary nucleus* | 8.2 | (1.0) | 104† | (18) | 57¶ | (10) |
| Ventromedial nucleus* | 12 | (2.1) | 71‡; | (16) | 49‡ | (7.8) |
| Thalamus | ||||||
| Anterodorsal nucleus | 87 | (15) | 75 | (13) | 68 | (12) |
| Anteroventral nucleus* | 62 | (9.7) | 137‡ | (12) | 141‡ | (18) |
| Lateral geniculate nucleus* | 258 | (35) | 445‡ | (68) | 456‡ | (61) |
| Medial geniculate body* | 123 | (17) | 713† | (40) | 373¶ | (52) |
| Posterior intralaminar nucleus* | 19 | (2.1) | 90† | (6.3) | 33 | (4.9) |
| Subparafascicular nucleus* | 17 | (3.3) | 215† | (19) | 111¶ | (16) |
| Midbrain, Pons, Modulla | ||||||
| Dorsolateral central gray* | 21 | (4.7) | 280† | (18) | 114¶ | (9.1) |
| Lateroventral central gray* | 37 | (9.2) | 132† | (16) | 61 | (12) |
| Cochlear nuclei* | 194 | (38) | 943‡ | (135) | 914‡ | (95) |
| Cuneiform nucleus* | 20 | (3.6) | 136† | (11) | 45 | (6.1) |
| Inferior colliculus cen/dor* | 965 | (109) | 2001‡ | (167) | 1977‡ | (198) |
| Inferior colliculus external* | 1140 | (111) | 2772‡ | (217) | 2311‡ | (131) |
| Nuc lateral lemniscus* | 108 | (16) | 667‡ | (34) | 644‡ | (51) |
| Nuc trapezoid bodies* | 46 | (4.8) | 445‡ | (31) | 383‡ | (43) |
| Superior olivary complex* | 54 | (5.9) | 408‡ | (39) | 372‡ | (20) |
| Locus coeruleus* | 3.6 | (0.6) | 12‡ | (2.3) | 7.5 | (0.7) |
| Raphe dorsal | 29 | (10) | 67 | (15) | 35 | (6.3) |
| Dorsal tegmental nucleus | 26 | (6.6) | 40 | (6.1) | 49 | (12) |
| Ventral tegmental nucleus | 21 | (4.3) | 28 | (0.7) | 28 | (2.8) |
| Cerebellum | ||||||
| Hemispheres* | 2149 | (547) | 4563 | (547) | 5342‡ | (997) |
| Vermis* | 3211 | (667) | 9081‡ | (1146) | 10,756‡ | (1283) |
Mean integrated gray values (divided by 100) measured in the Naïve (n6), Acute (n6), and Chronic (n6) groups (SEM).
*
One-way ANOVA, p ≤ 0.02 (all significant areas are presented in bold characters to facilitate the visualization of areas activated by loud noise).
†
Tukey’s HSD multiple means comparisons: p0.05 vs. Naive and Chronic groups.
‡
Tukey’s HSD multiple means comparisons: p0.05 vs. Naive group.
¶
Tukey’s HSD multiple means comparisons: p0.05 vs. Naïve and Acute groups.