Figure 1c:

Imaging and pathologic data for 67-year-old patient with PSA level, 9.4 ng/mL (9.4 μg/mL); PCa stage, T2a; and biopsy Gleason score, 6; resulting in combined MR imaging and MR spectroscopic imaging score of 1 (probable insignificant cancer). (a) MR spectroscopic imaging (volume excitation with water and lipid suppression by means of spectral-spatial pulses; 1000/130; chemical shift imaging matrix, 16 × 8 × 8; field of view, 110 × 55 × 55 mm; spatial resolution, 6.9 mm; one signal acquired; and imaging time, 17 minutes) grid superimposed on transverse T2-weighted MR image (4000/102; echo train length, 12; field of view, 14 cm; acquisition matrix, 256 × 192; section thickness, 3 mm; no intersection gap; and four signals acquired). (b) Corresponding spectroscopic grid shows voxel (*) suspicious for cancer. (c) Histopathologic section shows Gleason score, 6 (solid line); total volume, 0.357 cm³ (clinically insignificant cancer). (d) IHC staining of prostatectomy specimens from tissue section shown in c for Ki-67 (left), pAkt (middle), and AR (right).