. Author manuscript; available in PMC: 2010 Jan 1.

Published in final edited form as: Expert Rev Vaccines. 2009 Mar;8(3):299–312. doi: 10.1586/14760584.8.3.299

Table 1.

Enrichment markers for human memory T-cell subsets.

Marker	Expression enriched in subsets of:	Protein superfamily	Ref.
Cluster of differentiation others molecules

CD11a (LFA-1)	T_EM, T_CM	Integrin	[122]
CD11b^*	E	Integrin	[123]
IL-15Ra	T_CM, T_EM, E		[46,124]
CD25 (IL-2Ra)	E		[1,46]
IL-2/15Rb	N, T_CM, T_EM		[38,125]
CD27	N, T_CM	TNF receptor	[123]
CD28	N, T_CM	Immunoglobulin like	[123]
CD44^*	E, M	Cartilage link protein	[1,126,127]
CD45RA^‡	N, E	PTP receptor	[1,123]
CD45RO^‡	E, T_CM, T_EM	PTP receptor	[1]
CD49d^*	E, T_EM	Integrin	[98,123]
CD56	E, M	Immunoglobulin like	[128,129]
CD57	E		[123]
CD62L	N, T_CM	C-type lectin	[1,127]
CD69	E	C-type lectin	[1]
CD95 (Fas)	E, T_CM, T_EM	TNF receptor	[123,130]
CD95L (FasL)	E, T_CM, T_EM	TNF	[123,130]
CD127 (IL_7Ra)	T_CM, T_EM		[124]
CD137 (4–1BB)	E	TNF receptor	[131]
CD154 (CD40L)	E	TNF	[132]
CD134 (OX-40)	E	TNF receptor	[133]
CD152 (CTLA-4)	E	Immunoglobulin like	[134]

Chemokine receptors

CCR3	T_EM	GPCR	[28–31,135]
CCR5	T_EM, E	GPCR	[1,28–31,135–138]
CCR6	E, T_CM	GPCR	[1]
CCR7	N, T_CM	GPCR	[1]
CCR8	M	GPCR	[135]
CXCR3	E, M	GPCR	[1,135,138]
CXCR4	N, M	GPCR	[1,136]

Others

ICOS	E	Immunoglobulin like	[139]
Ly6c	M		[1]
PD-1	T_CM, T_EM		[113,140]
PNA ligand^*	E, M	O-glycan	[141]
1B11 ligand^*	E	O-glycan	[142]

Markers established for murine T cells only.

^‡

CD45RA and CD45RO are isoforms of the CD45 molecule.

E: Effector cell; GPCR: G protein-coupled receptor; M: Memory phenotype cells; N: Naive; PTP: Protein tyrosine phosphatase; T_CM: Central memory T cell; T_EM: Effector memory T cell.