Fig 4.
Upper. Hepatic mRNA expression of Nqo1, Gclc, and Ho-1 in wild-type mice after various doses of CDDO-Im. Livers were removed 6 h after dosing and mRNA quantified by the bDNA assay. Lower. Hepatic mRNA expression of Nqo1, Gclc, and Ho-1 in wild-type mice at different time points after CDDO-Im (1 mg/kg, i.p.) administration. mRNA was quantified by the bDNA assay. Data are expressed as relative to control mean ± S.E.M. Asterisks (*) indicate statistically significant differences between CDDO-Im treated and control groups (p ≤ 0.05).