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. Author manuscript; available in PMC: 2009 May 11.
Published in final edited form as: Thromb Haemost. 2009 Apr;101(4):724–733. doi: 10.1160/th08-10-0632

Figure 5. PAR1 dependent vascular barrier protection by APC in a modified Miles assay.

Figure 5

A) Male mice were infused with saline, murine APC or WE for 4.5 h and Evans blue was intravenously injected 30 min prior to the end of the infusion. At the end of the infusion 25 ng of murine VEGF was intradermally injected and 30 min later the injection sites were removed by punch biopsies. B) C57BL/6 wildtype mice were infused in parallel. Evans blue content in VEGF-injected skin is shown. C) Evans blue content of an additional set of parallel infused C57BL/6 wildtype and PAR1 deficient (PAR1 KO) animals. Means±SEM are shown in all panels, n=10 per group (B, C), P values are indicated.