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. Author manuscript; available in PMC: 2010 Mar 20.
Published in final edited form as: Neurosci Lett. 2009 Feb 4;452(3):258–261. doi: 10.1016/j.neulet.2009.01.078

Fig. 2. Inhibition of the development of cocaine-induced locomotor sensitization by daily pre-treatment with 40 mg/kg minocycline.

Fig. 2

Minocycline (Mino) or its vehicle (Ctrl) were administrated daily 3 h before i.p. injection of 10 mg/kg cocine (Co) or its vehicle (n = 6). Locomotor activity was measured for 30 min starting immediately after cocaine administration. Repeated ANOVA revealed that significant difference occurred between Co and Co + Mino groups, but not Ctrl and Mino groups [day, F (1, 20) = 4.63, p<0.05; group, F (3, 20) = 78.24, p<0.05; day × group, F (3, 20) = 2.85, p>0.05); * p<0.05 vs. corresponding Cocaine-treated group, t-test].