Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Oct 3;70(4):896–907. doi: 10.1111/j.1365-2958.2008.06452.x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Journal compilation © 2008 Blackwell Publishing

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

PMC Copyright notice

Fig. 1 — Model of the V. harveyi Quorum-Sensing Circuit. V. harveyi produces and detects three AIs and through modulation of the levels of the master transcriptional regulator, LuxR, controls downstream QS-target genes. The three AIs are: CAI-1 (circles) which binds to CqsS, HAI-1 (pentagons) which binds to LuxN and AI-2 (double pentagons) which binds to LuxPQ. At LCD, when LuxO is phosphorylated (LuxO˜P), it activates transcription of the genes encoding the five Qrr sRNAs which work in conjuction with Hfq to destabilize the mRNA of luxR. At HCD, when LuxO is not phosphorylated, qrr transcription ceases, luxR mRNA is stabilized and LuxR protein is produced. In a feedback loop, LuxR activates expression of qrr2, qrr3 and qrr4, which affects the timing of the QS transitions. OM, outer membrane; IM, inner membrane.